It follows a lengthy PSNI investigation into the use of the postal system to send drugs from across the Irish Sea to Derry.
As part of the probe, four people were arrested in England and Wales and brought back to Derry for questioning over the drug dealing racket.
The charges include being concerned in the supply of a class A controlled drug, conspiracy to supply a class A controlled drug, conspiracy to supply a class B controlled drug, Possessing criminal property and concealing criminal property.
They are due to appear in Derry Magistrates Court this morning, Thursday, May, 2. for a first remand hearing.
As is normal procedure, all charges will be reviewed by the PPS.
A third male was also arrested in relation to this on suspicion of being concerned in the supply of a class A controlled drug and being concerned in the supply of a class B controlled drug.
He remains in custody at this time.
The arrests follow a proactive investigation into the supply of controlled drugs through the postal system, ongoing over the last year.
Security sources said the long-running investigation “demonstrated the scale of the operation and our commitment to bring those who are intent on supplying illegal drugs to justice, therefore protecting our community”.