Ciaran O’Neill is the owner of the award winning Bishop’s Gate Hotel.
It is one of a number of businesses that have had to temporarily close after staff tested positive for the virus.
It shut its doors to the public on Monday and is currently going through a deep clean of the premises to protect staff and patrons.
It will reopen at 5 pm tomorrow, Wednesday, September 30.
Hotels, restaurants and food serving pubs re-opened to the public on Friday, July 3 after three months in lockdown.
Said Mr O’Neill: “I think all business are going to have to deal with it.
“We are one of many businesses in the same situation today.
“As the next week or 10 days goes on a lot of other businesses will have difficult decision to make about getting Covid under control,” he said.
Tighter localised Phase 3 restrictions in the Co Donegal in the Republic came into effect last Friday.
Pubs, hotels, restaurants and cafes in the North of Ireland will also be subject tougher restrictions this week.
First Minister Arlene Foster announced in the Assembly today that from midnight tomorrow, September 30, they must close their doors to the public at 11 pm.
Last orders for food and alcohol is at 10.30 pm and all patrons must be off the premises by 11 pm.