More than 100 healthcare staff have died with the virus across the UK, as have many transport and other key workers.
Across the North of Ireland, members of the public stopped their daily routine at 11 am to reflect on the lives lost.
In the Stormont Assembly chamber, MLAs halted business to observe the silence.
In the North of Ireland, 309 deaths linked to Covid-19 have been reported by the Department of Health, although it is understood no health workers here have died with the virus.
Those figures cover mainly hospital deaths and are expected to rise once deaths in care homes and in the community are taken into account.
Earlier on Tuesday, the PSNI and Department of Health issued a joint statement expressing “deep concern” that the the lockdown regulations were being undermined by an ongoing debate on the issue of people travelling by car for exercise.
They said it could encourage some people to ignore health advice “with potentially devastating consequences”.
Their overriding priority was the protection of life, they said, adding that the regulations were never going to cover all aspects of behaviour.
The advice is still for the public to stay at home, protect the NHS and save lives.
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